In order to satisfy the routine clinical application of PET, apply Positron radiopharmaceuticals is one of the primary matters. In nowadays, there are many applications in PET center have already researched and developed lots of the positron tracer, and there are not only worth the price but also implemented into the basic and clinical applications widely.

These positron tracers mainly applies for 11C, 13N, 150 AND 18F in order to gain the best PET imaging positron tracer within a short period. Thus, the small cyclotron is needed to be used in a certain period of time.

Cyclotron is the use of electrically charged ions, neutrons or charged protons in the accelerator by changing the magnetic field to accelerate particles to high energy particles, obtained after the bombardment of the target material, so that the needs of the target material and produces radioisotope.  The electronic accelerator has been implemented for most of the cyclotrons recently. These positron is able to be accelerated to 10-18 Mev Engery ( Million electronic voltage) . The normal cyclotron accelerator could produce 2 to 6 radioisotope.